Granisetron hydrochloride |
 |
General information |
| Name: |
Granisetron hydrochloride |
| CAS: |
107007-99-8 |
| Molecular Formula: |
C18H25ClN4O |
| Physicochemical Property: |
White or almost white powder |
| File Status: |
|
| Packing: |
5KG/tin |
| Usage: |
treatment and prevention of nausea and vomiting caused by chemotherapy or radiation therapy |
| Store: |
To be stored in a dry light-protected place at a temperature not exceeding 30 ºС. |
Other information of Granisetron hydrochloride |
Appearance | White or almost white powder | Solubility | Freely soluble in water, sparingly soluble in methylene chloride, slightly soluble in methanol. | Identification | | IR spectrum Discrimination chloride | Concordant with the working standard. Forward reaction | pH | pH=4.0～6.5 | Related substances(HPLC) | Impurity A NMT 0.5% Impurity B NMT 0.5% Impurity C NMT 0.2% Impurity D NMT 0.1% | Impurity E（TLC） | NMT 0.5% | Any other impurity | NMT0.1% | Total impurity | NMT 1.0% | Sulphated ash | NMT 0.1% | Loss on drying | NMT 0.5% | Assay(HPLC) | 97% ~102% (dried substance) |
Granisetron(CAS:107007-99-8) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Granisetron(CAS:107007-99-8) main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. Granisetron(CAS:107007-99-8) does not have much effect on vomiting due to motion sickness. Granisetron CAS:107007-99-8 does not have any effect on dopamine receptors or muscarinic receptors. Granisetron CAS:107007-99-8 is a well-tolerated drug with few side effects. |
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